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The last proposed system of RBC vasodilation from the existence of nitrite would be the reduction of nitrite to NO by Hb. Brooks first analyzed the nitrite Hb conversation in 1937 and this work was afterwards extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to type metHb and NO (Brooks, 1937; Doyle e